Escola Paulista de Medicina
Molecular Biology Graduate Program

PD Scholarship in Study of Pathogenesis and Development of Antiviral Potentials for COVID-19

Field of knowledge: Cellular and Molecular Biology
FAPESP process No.: 2020 / 04899-1
Project title: Interaction of SARS-CoV-2 Surface Protein (Spike Protein) with Heparin: Therapeutic Potential
Area: Cellular and Molecular Biology
Number of vacancies: 1
Principal researcher: Helena Bonciani Nader Published on: 05/04/2020
Deadline for registration: 05/18/2020
Registration: This email address is being protected from spambots. You need JavaScript enabled to view it.

Unit / Institution: Discipline of Molecular Biology, Department of Biochemistry, Institute of Pharmacology and Molecular Biology / Paulista School of Medicine, Federal University of São Paulo
Location: Rua Três de Maio, 100 - Vila Clementino, São Paulo, SP, 04044-020
Requirements:
The candidate must have a good academic record, and full training in methodologies, given the urgency in carrying out the project. The vacancy is open to Brazilians and foreigners.
Candidates must submit a brief summary of their qualifications to meet the proposal, citing the main laboratory techniques you are familiar with and a copy of the updated CV Lattes.
Experimental approach:
Pharmaceutical preparations of heparin and LMWH and their derivatives will be subfractionated to select those with high antiviral, anti-inflammatory and anticoagulant potential. The studies will be carried out using advanced sequencing (MS / HPLC) and spectroscopic (NMR) techniques, to determine which structural characteristics of GAGs lead to high bioactivity (blocking Spike Protein binding, anticoagulant and anti-inflammatory activity) thus defining which saccharides they are viable inhibitors of viral binding and invasion, anticoagulants and anti-inflammatory drugs. These saccharides can be optimized and refined from biologically active subfractions of heparin and other GAGs already approved as pharmaceutical products. The PD researcher will also be involved in purifying recombinant protein expression and viral infection cell models. Experience in the areas of cellular and molecular biology will then be required.

Rua Três de Maio, 100, 4° andar, CEP: 04044-020, Vila Clementino, São Paulo - SP.

Telefone: (11) 55764444 Voip: 1186/1180    (Patrícia - patriciacp.bioq@gmail.com / Maurício - capu.cim@gmail.com)